Detoxification Report

Detoxification is the physiological removal of toxic substances from the human body. It is mainly carried out by the liver, and to a lesser extent the small intestine, kidneys and lungs. Substances such as nutrients, food additives, pesticides, medications, air pollutants, alcohol and hormones are transformed from being fat-soluble to water-soluble, allowing them to be more easily excreted from the body. The process occurs in two major phases: Phase I primes toxic molecules for deactivation and Phase II finishes the deactivation and prepares for elimination.

Poor detoxification can cause symptoms such as headaches, muscle aches, fatigue, allergies, skin disorders, weight gain, bloating, acid reflux and heartburn, excessive sweating, chronic infections, subfertility, low libido, poor mental function and low stress tolerance.

The Detoxification Report examines genes that impact Phase I reactions in the liver, including cytochrome P450 enzymes; Phase II conjugation, including the UDP-glucuronosyltransferases (UGTs) and glutathione S-transferases (GSTs); and Phase III transport, whereby ATP-binding cassette (ABC) efflux transporters pump toxins and drugs out of the body. It also includes antioxidant defence genes that help neutralise ROS generated during Phase I and metallothioneins (MTs) that protect against heavy metal toxicity. The report provides personalised nutritional and lifestyle recommendations to optimise detoxification.

All of the Lifecode Gx reports include

• personalised, colour coded genotype results

• gene function and SNP impact descriptions

• clinically relevant SNPs

• nutrient and other epigenetic impacts

• links to research evidence